Thyroid Metastasis from Nonsmall Cell Lung Cancer

Abstract EN

Background.

Thyroid metastases are rare.

Clinically, they represent less than 4% of thyroid malignancy in clinical studies.

Aim.

To assess various presentations and therapy for patients with lung cancer metastatic in the thyroid.

Materials and Methods.

We report a case of metastatic adenocarcinoma of the lung to the thyroid.

We reviewed similar reports through PubmMed search from 1997 until 2013.

Case Presentation.

A 48-year-old lady was seen in the clinic for an adenocarcinoma of left upper lobe (LUL) of the lung; she received neoadjuvant chemotherapy then LUL lobectomy.

After 9 months she presented with diffuse goiter initially believed to be a solitary metastatic lesion as it was positive for adenocarcinoma of lung origin on histopathological exam with TTF-1 positivity.

Unfortunately, PET scan showed additional mediastinal lymphadenopathy.

Conclusion.

The treatment strategy for metastatic thyroid disease is based on a multidisciplinary approach, where thyroidectomy would have been considered in case of a solitary metastatic involvement, but further metastatic workup is mandated to direct further systemic therapy versus palliative radiation therapy.