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Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease
Joint Authors
Sheppard, Dean
Katsumoto, Tamiko R.
Violette, Shelia M.
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Interstitial lung disease (ILD) is a commonly encountered complication of systemic sclerosis (SSc) and accounts for a significant proportion of SSc-associated morbidity and mortality.
Its pathogenesis remains poorly understood, and therapies that treat SSc ILD are suboptimal, at best.
SSc ILD pathogenesis may share some common mechanisms with other fibrotic lung diseases, in which dysregulation of lung epithelium can contribute to pathologic fibrosis via recruitment or in situ generation and activation of fibroblasts.
TGFβ, a master regulator of fibrosis, is tightly regulated in the lung by the integrin αvβ6, which is expressed at low levels on healthy alveolar epithelial cells but is highly induced in the setting of lung injury or fibrosis.
Here we discuss the biology of αvβ6 and present this integrin as a potentially attractive target for inhibition in the setting of SSc ILD.
American Psychological Association (APA)
Katsumoto, Tamiko R.& Violette, Shelia M.& Sheppard, Dean. 2011. Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454628
Modern Language Association (MLA)
Katsumoto, Tamiko R.…[et al.]. Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. International Journal of Rheumatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454628
American Medical Association (AMA)
Katsumoto, Tamiko R.& Violette, Shelia M.& Sheppard, Dean. Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454628