Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease

Joint Authors

Sheppard, Dean
Katsumoto, Tamiko R.
Violette, Shelia M.

Source

International Journal of Rheumatology

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-10-16

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Interstitial lung disease (ILD) is a commonly encountered complication of systemic sclerosis (SSc) and accounts for a significant proportion of SSc-associated morbidity and mortality.

Its pathogenesis remains poorly understood, and therapies that treat SSc ILD are suboptimal, at best.

SSc ILD pathogenesis may share some common mechanisms with other fibrotic lung diseases, in which dysregulation of lung epithelium can contribute to pathologic fibrosis via recruitment or in situ generation and activation of fibroblasts.

TGFβ, a master regulator of fibrosis, is tightly regulated in the lung by the integrin αvβ6, which is expressed at low levels on healthy alveolar epithelial cells but is highly induced in the setting of lung injury or fibrosis.

Here we discuss the biology of αvβ6 and present this integrin as a potentially attractive target for inhibition in the setting of SSc ILD.

American Psychological Association (APA)

Katsumoto, Tamiko R.& Violette, Shelia M.& Sheppard, Dean. 2011. Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454628

Modern Language Association (MLA)

Katsumoto, Tamiko R.…[et al.]. Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. International Journal of Rheumatology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454628

American Medical Association (AMA)

Katsumoto, Tamiko R.& Violette, Shelia M.& Sheppard, Dean. Blocking TGFβ via Inhibition of the αvβ6 Integrin : A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454628

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-454628