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Differential Expression ESTs Associated with Fluorosis in Rats Liver
Joint Authors
Zhao, R.
Pan, Y.
He, Y. Q.
Ying, L. J.
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The fluoride has volcanic activity and abundantly exists in environment combining with other elements as fluoride compounds.
Recent researches indicated that the molecular mechanisms of intracellular fluoride toxicity were very complex.
However, the molecular mechanisms underlying the effects on gene expression of chronic fluoride-induced damage is unknown, especially the detailed regulatory process of mitochondria.
In the present study, we screened the differential expression ESTs associated with fluorosis by DDRT-PCR in rat liver.
We gained 8 genes, 3 new ESTs, and 1 unknown function sequence and firstly demonstrated that microsomal glutathione S-transferase 1 (MGST1), ATP synthase H+ transporting mitochondrial F0 complex subunit C1, selenoprotein S, mitochondrial IF1 protein, and mitochondrial succinyl-CoA synthetase alpha subunit were participated in mitochondria metabolism, functional and structural damage process caused by chronic fluorosis.
This information will be very helpful for understanding the molecular mechanisms of fluorosis.
American Psychological Association (APA)
He, Y. Q.& Pan, Y.& Ying, L. J.& Zhao, R.. 2012. Differential Expression ESTs Associated with Fluorosis in Rats Liver. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454642
Modern Language Association (MLA)
He, Y. Q.…[et al.]. Differential Expression ESTs Associated with Fluorosis in Rats Liver. Comparative and Functional Genomics No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-454642
American Medical Association (AMA)
He, Y. Q.& Pan, Y.& Ying, L. J.& Zhao, R.. Differential Expression ESTs Associated with Fluorosis in Rats Liver. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454642