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Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
Joint Authors
Patel, Amit N.
Prajapati, Shailesh T.
Patel, Chhaganbhai N.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design.
The ratio of HPMC K4M and PVP K30 (X1) and the concentration of melt binder (X2) were selected as independent variables, and drug release at 1 hr (Q1), 4 hr (Q4), 8 hr (Q8), diffusion coefficient (n), and release rate constant (K) were selected as a dependent variable.
Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters.
It was observed that concentration of melt binder had significant effect on Q1, Q4, n, and K Binder concentration 25% w/w was found optimum.
Optimized formulation (F7) showed good similarity with theoretical profile of drug.
The X2 variable had a significant effect on dependent variables, and the X1 variable had no significant effect on dependent variables.
American Psychological Association (APA)
Prajapati, Shailesh T.& Patel, Amit N.& Patel, Chhaganbhai N.. 2011. Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-454644
Modern Language Association (MLA)
Prajapati, Shailesh T.…[et al.]. Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique. ISRN Pharmaceutics No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-454644
American Medical Association (AMA)
Prajapati, Shailesh T.& Patel, Amit N.& Patel, Chhaganbhai N.. Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-454644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454644