New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion
Joint Authors
El Ghazi, Issam
Armitage, Ian M.
Martin, Bruce L.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metallothionein 3 (MT-3), also known as growth inhibitory factor (GIF), exhibits a neuroinhibitory activity.
Our lab and others have previously shown that this biological activity involves interacting protein partners in the brain.
However, nothing specific is yet known about which of these interactions is responsible for the GIF activity.
In this paper, we are reporting upon new proteins found interacting with MT-3 as determined through immunoaffinity chromatography and mass spectrometry.
These new partner proteins—Exo84p, 14-3-3 Zeta, α and β Enolase, Aldolase C, Malate dehydrogenase, ATP synthase, and Pyruvate kinase—along with those previously identified have now been classified into three functional groups: transport and signaling, chaperoning and scaffolding, and glycolytic metabolism.
When viewed together, these interactions support a proposed model for the regulation of the GIF activity of MT-3.
American Psychological Association (APA)
El Ghazi, Issam& Martin, Bruce L.& Armitage, Ian M.. 2010. New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-454671
Modern Language Association (MLA)
El Ghazi, Issam…[et al.]. New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-454671
American Medical Association (AMA)
El Ghazi, Issam& Martin, Bruce L.& Armitage, Ian M.. New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-454671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454671