![](/images/graphics-bg.png)
A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin
Joint Authors
Behbehani, Gholamreza Rezaei
Barzegar, Lyla
Saboury, Ali Akbar
Mohebbian, M.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The interaction of Cu2+ with the first 16 residues of the Alzheimer's amyliod β peptide, Aβ(1–16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution.
The solvation parameters recovered from the extended solvation model indicate that HSA is involved in the transport of copper ion.
Complexes between Aβ(1–16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer's disease, where Cu2+ is involved in Aβ(1–16) aggregation.
The indexes of stability indicate that HSA removed Cu2+ from Aβ(1–16), rapidly, decreased Cu-induced aggregation of Aβ(1–16), and reduced the toxicity of Aβ(1–16) + Cu2+ significantly.
American Psychological Association (APA)
Behbehani, Gholamreza Rezaei& Barzegar, Lyla& Mohebbian, M.& Saboury, Ali Akbar. 2012. A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin. Bioinorganic Chemistry and Applications،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-454672
Modern Language Association (MLA)
Behbehani, Gholamreza Rezaei…[et al.]. A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin. Bioinorganic Chemistry and Applications No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-454672
American Medical Association (AMA)
Behbehani, Gholamreza Rezaei& Barzegar, Lyla& Mohebbian, M.& Saboury, Ali Akbar. A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin. Bioinorganic Chemistry and Applications. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-454672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454672