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Immune Escape Mechanisms in Diffuse Large B-Cell Lymphoma
Joint Authors
Procházka, V.
Papajík, T.
Jarosova, Marie
Indrak, Karel
Prouzová, Z.
Nedomová, R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphomas in Western countries.
Implementation of immunotherapy using monoclonal antibodies to therapeutic protocols has led to dramatic improvements in overall survival.
DLBCL became a model of a successful immunochemotherapy concept.
Despite this fact, there is still a proportion of patients who do not respond to or relapse early after treatment.
Growing evidence suggests that host antitumor immunity is suppressed by lymphoma cells in many ways.
First, host cytotoxic T cells are directly suppressed by interaction with programmed cell death (PD) ligand on lymphoma cell surface and a similar mechanism enhances the activity of suppressive regulatory T cells (Tregs).
Second, tumor cells escape host cytotoxic cells due to lower immunogenicity caused by reduced expression of HLA antigens.
Both mechanisms have an origin in primary genetic events in lymphomagenesis.
Rearrangement of MHC class II transcriptional activator (CIITA) gene and amplification of Janus kinase (JAK2) gene lead to enhanced expression of PD ligands 1 and 2, higher proliferation activity, and lower expression of HLA.
This paper summarizes current knowledge about clinically relevant immune escape mechanisms in DLBCL.
American Psychological Association (APA)
Procházka, V.& Jarosova, Marie& Prouzová, Z.& Nedomová, R.& Papajík, T.& Indrak, Karel. 2012. Immune Escape Mechanisms in Diffuse Large B-Cell Lymphoma. ISRN Immunology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454688
Modern Language Association (MLA)
Procházka, V.…[et al.]. Immune Escape Mechanisms in Diffuse Large B-Cell Lymphoma. ISRN Immunology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-454688
American Medical Association (AMA)
Procházka, V.& Jarosova, Marie& Prouzová, Z.& Nedomová, R.& Papajík, T.& Indrak, Karel. Immune Escape Mechanisms in Diffuse Large B-Cell Lymphoma. ISRN Immunology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454688