Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?
Joint Authors
Zheng, Q.
Zhang, C.
Karsdal, Morten A.
Sørensen, M. G.
Wang, Y.
Henriksen, K.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Drug development for dementias is significantly hampered by the lack of easily accessible biomarkers.
Fluid biomarkers of dementias provide indications of disease stage, but have little prognostic value, cannot detect early pathological changes, and can only be measured in CSF (cerebrospinal fluid) which significantly limits their applicability.
In contrast, imaging based biomarkers can provide indications of probability of disease progression, yet are limited in applicability due to cost, radiation and radio-tracers.
These aspects highlight the need for other approaches to the development of biomarkers of dementia, which should focus on not only providing information about pathological changes, but also on being measured easily and reproducibly.
For other diseases, focus on development of assays monitoring highly specific protease-generated cleavage fragments of proteins has provided assays, which in serum or plasma have the ability to predict early pathological changes.
Proteolytic processing of brain proteins, such as tau, APP, and α-synuclein, is a key pathological event in dementias.
Here, we speculate that aiming biomarker development for dementias at detecting small brain protein degradation fragments of generated by brain-derived proteases specifically in blood samples could lead to the development of novel markers of disease progression, stage and importantly of treatment efficacy.
American Psychological Association (APA)
Wang, Y.& Sørensen, M. G.& Zheng, Q.& Zhang, C.& Karsdal, Morten A.& Henriksen, K.. 2012. Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-454740
Modern Language Association (MLA)
Wang, Y.…[et al.]. Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-454740
American Medical Association (AMA)
Wang, Y.& Sørensen, M. G.& Zheng, Q.& Zhang, C.& Karsdal, Morten A.& Henriksen, K.. Will Posttranslational Modifications of Brain Proteins Provide Novel Serological Markers for Dementias?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-454740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454740