Vascular Complications and Diabetes : Current Therapies and Future Challenges
Joint Authors
Willard, Abbott L.
Herman, Ira M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Diabetic retinal complications, including macular edema (DME) and proliferative diabetic retinopathy (PDR), are the leading cause of new cases of blindness among adults aged 20–74.
Chronic hyperglycemia, considered the underlying cause of diabetic retinopathy, is thought to act first through violation of the pericyte-endothelial coupling.
Disruption of microvascular integrity leads to pathologic consequences including hypoxia-induced imbalance in vascular endothelial growth factor (VEGF) signaling.
Several anti-VEGF medications are in clinical trials for use in arresting retinal angiogenesis arising from DME and PDR.
Although a review of current clinical trials shows promising results, the lack of large prospective studies, head-to-head therapeutic comparisons, and potential long-term and systemic adverse events give cause for optimistic caution.
Alternative therapies including targeting pathogenic specific angiogenesis and mural-cell-based therapeutics may offer innovative solutions for currently intractable clinical problems.
This paper describes the mechanisms behind diabetic retinal complications, current research supporting anti-VEGF medications, and future therapeutic directions.
American Psychological Association (APA)
Willard, Abbott L.& Herman, Ira M.. 2012. Vascular Complications and Diabetes : Current Therapies and Future Challenges. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-454755
Modern Language Association (MLA)
Willard, Abbott L.& Herman, Ira M.. Vascular Complications and Diabetes : Current Therapies and Future Challenges. Journal of Ophthalmology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-454755
American Medical Association (AMA)
Willard, Abbott L.& Herman, Ira M.. Vascular Complications and Diabetes : Current Therapies and Future Challenges. Journal of Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-454755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454755