Targeting the Insulin-Like Growth Factor Pathway in Rhabdomyosarcomas : Rationale and Future Perspectives
Joint Authors
Martins, Ana Sofia
Missiaglia, Edoardo
Shipley, Janet
Olmos, David
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rhabdomyosarcomas (RMS) are a heterogeneous group of tumors that share features of skeletal myogenesis and represent the most common pediatric soft tissue sarcoma.
Even though significant advances have been achieved in RMS treatment, prognosis remains very poor for many patients.
Several elements of the Insulin-like Growth Factor (IGF) pathway are involved in sarcomas, including RMS.
The IGF2 ligand is highly expressed in most, if not all, RMS, and frequent overexpression of the receptor IGF1R is also found.
This is confirmed here through mining expression profiling data of a large series of RMS samples.
IGF signaling is implicated in the genesis, growth, proliferation, and metastasis of RMS.
Blockade of this pathway is therefore a potential therapeutic strategy for the treatment of RMS.
In this paper we examine the biological rationale for targeting the IGF pathway in RMS as well as the current associated preclinical and clinical experience.
American Psychological Association (APA)
Martins, Ana Sofia& Olmos, David& Missiaglia, Edoardo& Shipley, Janet. 2011. Targeting the Insulin-Like Growth Factor Pathway in Rhabdomyosarcomas : Rationale and Future Perspectives. Sarcoma،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-454782
Modern Language Association (MLA)
Martins, Ana Sofia…[et al.]. Targeting the Insulin-Like Growth Factor Pathway in Rhabdomyosarcomas : Rationale and Future Perspectives. Sarcoma No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-454782
American Medical Association (AMA)
Martins, Ana Sofia& Olmos, David& Missiaglia, Edoardo& Shipley, Janet. Targeting the Insulin-Like Growth Factor Pathway in Rhabdomyosarcomas : Rationale and Future Perspectives. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-454782
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454782