Safety and Efficacy of Erythropoietin in Traumatic Brain Injury Patients : A Pilot Randomized Trial
Joint Authors
Nirula, R.
Waxman, K. S.
Diaz-Arrastia, R.
Weigelt, J. A.
Brasel, K.
Source
Critical Care Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Erythropoietin (EPO) is a neuroprotective agent utilized in stroke patients.
This pilot study represents the first randomized trial of EPO in traumatic brain injury (TBI) patients.
Methods.
Adult, blunt trauma patients with evidence of TBI were randomized to EPO or placebo within 6 hours of injury.
Baseline and daily serum S-100B and Neuron Specific Enolase (NSE) levels were measured.
Results.
TBI was worse in the EPO (n=11) group compared to placebo patients (n=5).
The use of EPO did not impact NSE (P=.89) or S100 B (P=.53) levels compared to placebo.
Conclusions.
At the dose used, EPO did not reduce neuronal cell death compared to placebo; however, TBI severity was worse in the EPO group while levels of NSE and S100-B were similar to the less injured placebo group making it difficult to rule out a treatment effect.
A larger, balanced study is necessary to confirm a potential treatment effect.
American Psychological Association (APA)
Nirula, R.& Diaz-Arrastia, R.& Brasel, K.& Weigelt, J. A.& Waxman, K. S.. 2010. Safety and Efficacy of Erythropoietin in Traumatic Brain Injury Patients : A Pilot Randomized Trial. Critical Care Research and Practice،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454800
Modern Language Association (MLA)
Nirula, R.…[et al.]. Safety and Efficacy of Erythropoietin in Traumatic Brain Injury Patients : A Pilot Randomized Trial. Critical Care Research and Practice No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-454800
American Medical Association (AMA)
Nirula, R.& Diaz-Arrastia, R.& Brasel, K.& Weigelt, J. A.& Waxman, K. S.. Safety and Efficacy of Erythropoietin in Traumatic Brain Injury Patients : A Pilot Randomized Trial. Critical Care Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454800