Antibody-Mediated Rejection : An Evolving Entity in Heart Transplantation
Joint Authors
Rao, Vivek
Tinckam, Kathryn
Chih, Sharon
Chruscinski, Andrzej
Butany, Jagdish
Ross, Heather J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Antibody-mediated rejection (AMR) is gaining increasing recognition as a major complication after heart transplantation, posing a significant risk for allograft failure, cardiac allograft vasculopathy, and poor survival.
AMR results from activation of the humoral immune arm and the production of donor-specific antibodies (DSA) that bind to the cardiac allograft causing myocardial injury predominantly through complement activation.
The diagnosis of AMR has evolved from a clinical diagnosis involving allograft dysfunction and the presence of DSA to a primarily pathologic diagnosis based on histopathology and immunopathology.
Treatment for AMR is multifaceted, targeting inhibition of the humoral immune system at different levels with emerging agents including proteasome and complement inhibitors showing particular promise.
While there have been significant advances in our current understanding of the pathogenesis, diagnosis, and treatment of AMR, further research is required to determine optimal diagnostic tools, therapeutic agents, and timing of treatment.
American Psychological Association (APA)
Chih, Sharon& Chruscinski, Andrzej& Ross, Heather J.& Tinckam, Kathryn& Butany, Jagdish& Rao, Vivek. 2012. Antibody-Mediated Rejection : An Evolving Entity in Heart Transplantation. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454816
Modern Language Association (MLA)
Chih, Sharon…[et al.]. Antibody-Mediated Rejection : An Evolving Entity in Heart Transplantation. Journal of Transplantation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-454816
American Medical Association (AMA)
Chih, Sharon& Chruscinski, Andrzej& Ross, Heather J.& Tinckam, Kathryn& Butany, Jagdish& Rao, Vivek. Antibody-Mediated Rejection : An Evolving Entity in Heart Transplantation. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454816