Antiobesity Effect of Codonopsis lanceolata in High-CalorieHigh-Fat-Diet-Induced Obese Rats
Joint Authors
Choung, Se-Young
Choi, Hye-Kyung
Jang, Young Pyo
Won, Eun-Kyung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The antiobesity effects of Codonopsis lanceolata (CL) were evaluated in a high-calorie/high-fat-diet (HFD-) induced obesity rat model and 3T3-L1 cells.
The Sprague-Dawley male rats were fed a normal diet (ND) or a HFD for a period of 12 weeks.
The rats were subdivided into groups: ND, ND + wild Codonopsis lanceolata (wCL) (900 mg/kg/day, p.o.), ND + cultivated Codonopsis lanceolata (cCL) (900 mg/kg/day, p.o.), HFD, HFD + wCL (100, 300, or 900 mg/kg/day, p.o.), HFD + cCL (100, 300, or 900 mg/kg/day, p.o.), and HFD + sibutramine.
The body weight gains of the administered HFD + CL (wCL or CCL) were lower than those of the rats fed with only the HFD group.
Moreover, the weight of adipose pads and the serum levels of triglycerides, total cholesterol, and low density lipoprotein cholesterol in the group administered HDL + CL were significantly lower than in the HFD group.
The inhibitory effect of lipid accumulation in 3T3-L1 cells was measured by Oil Red O staining and reverse transcription-polymerase chain reaction (RT-PCR).
Treatment of 3T3-L1 cells with wCL inhibited lipid accumulation and expression of C/EBPα and PPARγ.
These results suggest that CL has a great potential as a functional food with anti-obesity effects and as a therapeutic alternative in the treatment of obesity.
American Psychological Association (APA)
Choi, Hye-Kyung& Won, Eun-Kyung& Jang, Young Pyo& Choung, Se-Young. 2013. Antiobesity Effect of Codonopsis lanceolata in High-CalorieHigh-Fat-Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454823
Modern Language Association (MLA)
Choi, Hye-Kyung…[et al.]. Antiobesity Effect of Codonopsis lanceolata in High-CalorieHigh-Fat-Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-454823
American Medical Association (AMA)
Choi, Hye-Kyung& Won, Eun-Kyung& Jang, Young Pyo& Choung, Se-Young. Antiobesity Effect of Codonopsis lanceolata in High-CalorieHigh-Fat-Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454823