Dopamine D2 Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly
Joint Authors
Ejendal, Karin F. K.
Watts, Val J.
Hébert, Terence E.
Dessauer, Carmen W.
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic dopamine receptor activation is implicated in several central nervous system disorders.
Although acute activation of Gαi-coupled D2 dopamine receptors inhibits adenylyl cyclase, persistent activation enhances adenylyl cyclase activity, a phenomenon called heterologous sensitization.
Previous work revealed a requirement for Gαs in D2-induced heterologous sensitization of AC5.
To elucidate the mechanism of Gαs dependency, we expressed Gαs mutants in Gαs-deficient GnasE2−/E2− cells.
Neither Gαs-palmitoylation nor Gαs-Gβγ interactions were required for sensitization of AC5.
Moreover, we found that coexpressing βARKct-CD8 or Sar1(H79G) blocked heterologous sensitization.
These studies are consistent with a role for Gαs-AC5 interactions in sensitization however, Gβγ appears to have an indirect role in heterologous sensitization of AC5, possibly by promoting proper signalosome assembly.
American Psychological Association (APA)
Ejendal, Karin F. K.& Dessauer, Carmen W.& Hébert, Terence E.& Watts, Val J.. 2012. Dopamine D2 Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454827
Modern Language Association (MLA)
Ejendal, Karin F. K.…[et al.]. Dopamine D2 Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly. Journal of Signal Transduction No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-454827
American Medical Association (AMA)
Ejendal, Karin F. K.& Dessauer, Carmen W.& Hébert, Terence E.& Watts, Val J.. Dopamine D2 Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454827