Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3β Signaling
Joint Authors
Jeong, Sun-oh
Zheng, Min
Cho, Gyeong Jae
Chen, Yingqing
Joe, Yeonsoo
Uddin, Md. Jamal
Chung, Hun Taeg
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Endogenous carbon monoxide (CO) is produced by heme oxygenase-1 (HO)-1 which mediates the degradation of heme into CO, iron, and biliverdin.
Also, CO ameliorates the human inflammatory bowel diseases and ulcerative colitis.
However, the mechanism for the effect of CO on the inflammatory bowel disease has not yet been known.
In this study, we showed that CO significantly increases survival percentage, body weight, colon length as well as histologic parameters in DSS-treated mice.
In addition, CO inhalation significantly decreased DSS induced pro-inflammatory cytokines by inhibition of GSK-3β in mice model.
To support the in vivo observation, TNF-α, iNOS and IL-10 after CO and LiCl treatment were measured in mesenteric lymph node cells (MLNs) and bone marrow-derived macrophages (BMMs) from DSS treated mice.
In addition, we determined that CO potentially inhibited GSK-3β activation and decreased TNF-α and iNOS expression by inhibition of NF-κB activation in LPS-stimulated U937 and MLN cells pretreated with CO.
Together, our findings indicate that CO attenuates DSS-induced colitis via inhibition of GSK-3β signaling in vitro and in vivo.
Importantly, this is the first report that investigated the molecular mechanisms mediated the novel effects of CO via inhibition GSK-3β in DSS-induced colitis model.
American Psychological Association (APA)
Uddin, Md. Jamal& Jeong, Sun-oh& Zheng, Min& Chen, Yingqing& Cho, Gyeong Jae& Chung, Hun Taeg…[et al.]. 2013. Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3β Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454848
Modern Language Association (MLA)
Uddin, Md. Jamal…[et al.]. Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3β Signaling. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-454848
American Medical Association (AMA)
Uddin, Md. Jamal& Jeong, Sun-oh& Zheng, Min& Chen, Yingqing& Cho, Gyeong Jae& Chung, Hun Taeg…[et al.]. Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3β Signaling. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-454848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454848