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Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV) : Novel Metal-Based Complex with Promising Antitumor Potential
Joint Authors
Guo, Pu
Li, Qingshan
Gao, Zhuyan
Li, Yunlan
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Di-phenyl-di-(2,4-difluobenzohydroxamato)tin(IV)(DPDFT), a new metal-based arylhydroxamate antitumor complex, showed high in vivo and in vitro antitumor activity with relative low toxicity, but no data was reported regarding its pharmacokinetics and dependent toxicity.
In this paper, a rapid, sensitive, and reproducible HPLC method in vivo using Diamonsil ODS column with a mixture of methanol and phosphoric acid in water (30 : 70, V/V, pH 3.0) as mobile phase was developed and validated for the determination of DPDFT.
The plasma was deproteinized with methanol that contained acetanilide as the internal standard (I.S.).
The photodiode array detector was set at a wavelength of 228 nm at room temperature and a linear curve over the concentration range 0.1~25 μg·mL-1 (r = 0.9993) was obtained.
The method was used to determine the concentration-time profiles for DPDFT in the plasma after single intravenous administration with doses of 5, 10, 15 mg·kg-1 to rats.
The pharmacokinetics parameter calculations and modeling were carried out using the 3p97 software.
The results showed that the concentration-time curves of DPDFT in rat plasma could be fitted to two-compartment model.
American Psychological Association (APA)
Li, Yunlan& Gao, Zhuyan& Guo, Pu& Li, Qingshan. 2012. Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV) : Novel Metal-Based Complex with Promising Antitumor Potential. Bioinorganic Chemistry and Applications،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-454861
Modern Language Association (MLA)
Li, Yunlan…[et al.]. Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV) : Novel Metal-Based Complex with Promising Antitumor Potential. Bioinorganic Chemistry and Applications No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-454861
American Medical Association (AMA)
Li, Yunlan& Gao, Zhuyan& Guo, Pu& Li, Qingshan. Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV) : Novel Metal-Based Complex with Promising Antitumor Potential. Bioinorganic Chemistry and Applications. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-454861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454861