![](/images/graphics-bg.png)
The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage
Joint Authors
Gumerson, Jessica D.
Michele, Daniel E.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Muscular dystrophies are genetically diverse but share common phenotypic features of muscle weakness, degeneration, and progressive decline in muscle function.
Previous work has focused on understanding how disruptions in the dystrophin-glycoprotein complex result in muscular dystrophy, supporting a hypothesis that the muscle sarcolemma is fragile and susceptible to contraction-induced injury in multiple forms of dystrophy.
Although benign in healthy muscle, contractions in dystrophic muscle may contribute to a higher degree of muscle damage which eventually overwhelms muscle regeneration capacity.
While increased susceptibility of muscle to mechanical injury is thought to be an important contributor to disease pathology, it is becoming clear that not all DGC-associated diseases share this supposed hallmark feature.
This paper outlines experimental support for a function of the DGC in preventing muscle damage and examines the evidence that supports novel functions for this complex in muscle that when impaired, may contribute to the pathogenesis of muscular dystrophy.
American Psychological Association (APA)
Gumerson, Jessica D.& Michele, Daniel E.. 2011. The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-454873
Modern Language Association (MLA)
Gumerson, Jessica D.& Michele, Daniel E.. The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-454873
American Medical Association (AMA)
Gumerson, Jessica D.& Michele, Daniel E.. The Dystrophin-Glycoprotein Complex in the Prevention of Muscle Damage. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-454873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454873