Origins of Injection-Site Sarcomas in Cats : The Possible Role of Chronic Inflammation—A Review
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The etiology of feline injection-site sarcomas remains obscure.
Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats.
However, the available evidence suggests that this is not the case with feline injection-site sarcomas.
These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where foreign materials such as glass, plastics, and metal are the causal agent.
Tumors arising with these agents are associated with chronic inflammation at the injection or implantation sites.
Similar tumors have been observed, albeit infrequently, at microchip implantation sites, and these also are associated with chronic inflammation.
It is suggested that injection-site sarcomas in cats may arise at the administration site as a result of chronic inflammation, possibly provoked by adjuvant materials, with subsequent DNA damage, cellular transformation, and clonal expansion.
However, more fundamental research is required to elucidate the mechanisms involved.
American Psychological Association (APA)
Woodward, Kevin N.. 2011. Origins of Injection-Site Sarcomas in Cats : The Possible Role of Chronic Inflammation—A Review. ISRN Veterinary Science،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-454890
Modern Language Association (MLA)
Woodward, Kevin N.. Origins of Injection-Site Sarcomas in Cats : The Possible Role of Chronic Inflammation—A Review. ISRN Veterinary Science No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-454890
American Medical Association (AMA)
Woodward, Kevin N.. Origins of Injection-Site Sarcomas in Cats : The Possible Role of Chronic Inflammation—A Review. ISRN Veterinary Science. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-454890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454890