![](/images/graphics-bg.png)
Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen
Joint Authors
Ravindran, Sriram
Patston, Philip A.
Schapira, Marc
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The contact system of coagulation can be activated when in contact with biomaterials.
As collagen is being tested in novel biomaterials in this study, we have investigated how type IV collagen affects plasma kallikrein and C1-inhibitor.
Firstly, we showed C1-inhibitor binds to type IV collagen with a Kd of 0.86 μM.
The effects of type IV collagen on plasma kallikrein, factor XIIa, and β-factor XIIa activity and on C1-inhibitor function were determined.
Factor XIIa rapidly lost activity in the presence of type IV collagen, whereas plasma kallikrein and β-factor XIIa were more stable.
The rate of inhibition of plasma kallikrein by C1-inhibitor was decreased by type IV collagen in a dose-dependent manner.
These studies could be relevant to the properties of biomaterials, which contain collagen, and should be considered in the testing for biocompatibility.
American Psychological Association (APA)
Ravindran, Sriram& Schapira, Marc& Patston, Philip A.. 2012. Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-454921
Modern Language Association (MLA)
Ravindran, Sriram…[et al.]. Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen. International Journal of Biomaterials No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-454921
American Medical Association (AMA)
Ravindran, Sriram& Schapira, Marc& Patston, Philip A.. Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-454921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454921