Desmosomes In Vivo
Author
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The structure, function, and regulation of desmosomal adhesion in vivo are discussed.
Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”.
This is fundamental to tissue strength.
Almost all studies in culture are done on weakly adhesive, calcium-dependent desmosomes, although hyperadhesion can be readily obtained in confluent cell culture.
Calcium dependence is a default condition in vivo, found in wounds and embryonic development.
Hyperadhesion appears to be associated with an ordered arrangement of the extracellular domains of the desmosomal cadherins, which gives rise to the intercellular midline identified in ultrastructural studies.
This in turn probably depends on molecular order in the desmosomal plaque.
Protein kinase C downregulates hyperadhesion and there is preliminary evidence that it may also be regulated by tyrosine kinases.
Downregulation of desmosomes in vivo may occur by internalisation of whole desmosomes rather than disassembly.
Hyperadhesion has implications for diseases such as pemphigus.
American Psychological Association (APA)
Garrod, David. 2010. Desmosomes In Vivo. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-454923
Modern Language Association (MLA)
Garrod, David. Desmosomes In Vivo. Dermatology Research and Practice No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-454923
American Medical Association (AMA)
Garrod, David. Desmosomes In Vivo. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-454923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454923