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Gene-Drug Interaction in Stroke
Joint Authors
Paciaroni, Maurizio
Caso, Valeria
Agnelli, Giancarlo
Amici, Serena
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
The focus on genetics has produced a large number of studies with the objective of revealing the genetic basis of cerebrovascular diseases.
Furthermore, pharmacogenetic research has investigated the relation between genetic variability and drug effectiveness/toxicity.
This review will examine the implications of pharmacogenetics of stroke; data on antihypertensives, statins, antiplatelets, anticoagulants, and recombinant tissue plasminogen activator will be illustrated.
Several polymorphisms have been studied and some have been associated with positive drug-gene interaction on stroke, but the superiority of the genotype-guided approach over the clinical approach has not been proved yet; for this reason, it is not routinely recommended.
American Psychological Association (APA)
Amici, Serena& Paciaroni, Maurizio& Agnelli, Giancarlo& Caso, Valeria. 2011. Gene-Drug Interaction in Stroke. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-454928
Modern Language Association (MLA)
Amici, Serena…[et al.]. Gene-Drug Interaction in Stroke. Stroke Research and Treatment No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-454928
American Medical Association (AMA)
Amici, Serena& Paciaroni, Maurizio& Agnelli, Giancarlo& Caso, Valeria. Gene-Drug Interaction in Stroke. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-454928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454928