Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy
Joint Authors
Grote, C. W.
Geiger, P. C.
Morris, J. K.
Wright, Douglas E.
Ryals, J. M.
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Insulin signaling depends on tyrosine phosphorylation of insulin receptor substrates (IRSs) to mediate downstream effects; however, elevated serine phosphorylation of IRS impairs insulin signaling.
Here, we investigated IRS protein expression patterns in dorsal root ganglia (DRG) of mice and whether their signaling was affected by diabetes.
Both IRS1 and IRS2 are expressed in DRG; however, IRS2 appears to be the prevalent isoform and is expressed by many DRG neuronal subtypes.
Phosphorylation of Ser(731)IRS2 was significantly elevated in DRG neurons from type 1 and type 2 diabetic mice.
Additionally, Akt activation and neurite outgrowth in response to insulin were significantly decreased in DRG cultures from diabetic ob/ob mice.
These results suggest that DRG neurons express IRS proteins that are altered by diabetes similar to other peripheral tissues, and insulin signaling downstream of the insulin receptor may be impaired in sensory neurons and contribute to the pathogenesis of diabetic neuropathy.
American Psychological Association (APA)
Grote, C. W.& Morris, J. K.& Ryals, J. M.& Geiger, P. C.& Wright, Douglas E.. 2011. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454941
Modern Language Association (MLA)
Grote, C. W.…[et al.]. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy. Experimental Diabetes Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-454941
American Medical Association (AMA)
Grote, C. W.& Morris, J. K.& Ryals, J. M.& Geiger, P. C.& Wright, Douglas E.. Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454941