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The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
Joint Authors
Tjomsland, Vegard
Messmer, Davorka
Sandström, Per
Bratthäll, Charlotte
Borch, Kurt
Niklasson, Lina
Larsson, Marie
Druid, Henrik
Spångeus, Anna
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression.
The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDAC) regarding expression of inflammatory factors and infiltration of immune cells and their impact on the clinical outcome.
The PDAC tissues examined expressed significantly increased levels of immunomodulatory and chemotactic factors (IL-6, TGFβ, IDO, COX-2, CCL2, and CCL20) and immune cell-specific markers corresponding to macrophages, myeloid, and plasmacytoid dendritic cells (DCs) as compared to controls.
Furthermore, short-time survivors had the lowest levels of DC markers.
Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma.
Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients.
American Psychological Association (APA)
Tjomsland, Vegard& Niklasson, Lina& Sandström, Per& Borch, Kurt& Druid, Henrik& Bratthäll, Charlotte…[et al.]. 2011. The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454960
Modern Language Association (MLA)
Tjomsland, Vegard…[et al.]. The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma. Clinical and Developmental Immunology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-454960
American Medical Association (AMA)
Tjomsland, Vegard& Niklasson, Lina& Sandström, Per& Borch, Kurt& Druid, Henrik& Bratthäll, Charlotte…[et al.]. The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454960