ExcretedSecreted Proteins from Trypanosome Procyclic Strains
Joint Authors
Peltier, Jean-Benoit
Geiger, Anne
Cuny, Gerard
Rofidal, Valerie
Sommerer, Nicolas
Atyame Nten, Celestine Michelle
Rossignol, Michel
Hirtz, Christophe
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Trypanosoma secretome was shown to be involved in parasite virulence and is suspected of interfering in parasite life-cycle steps such as establishment in the Glossina midgut, metacyclogenesis.
Therefore, we attempted to identify the proteins secreted by procyclic strains of T.
brucei gambiense and T.
brucei brucei, responsible for human and animal trypanosomiasis, respectively.
Using mass spectrometry, 427 and 483 nonredundant proteins were characterized in T.
brucei brucei and T.
brucei gambiense secretomes, respectively; 35% and 42% of the corresponding secretome proteins were specifically secreted by T.
brucei brucei and T.
brucei gambiense, respectively, while 279 proteins were common to both subspecies.
The proteins were assigned to 12 functional classes.
Special attention was paid to the most abundant proteases (14 families) because of their potential implication in the infection process and nutrient supply.
The presence of proteins usually secreted via an exosome pathway suggests that this type of process is involved in trypanosome ESP secretion.
The overall results provide leads for further research to develop novel tools for blocking trypanosome transmission.
American Psychological Association (APA)
Atyame Nten, Celestine Michelle& Sommerer, Nicolas& Rofidal, Valerie& Hirtz, Christophe& Rossignol, Michel& Cuny, Gerard…[et al.]. 2009. ExcretedSecreted Proteins from Trypanosome Procyclic Strains. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-454961
Modern Language Association (MLA)
Atyame Nten, Celestine Michelle…[et al.]. ExcretedSecreted Proteins from Trypanosome Procyclic Strains. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-454961
American Medical Association (AMA)
Atyame Nten, Celestine Michelle& Sommerer, Nicolas& Rofidal, Valerie& Hirtz, Christophe& Rossignol, Michel& Cuny, Gerard…[et al.]. ExcretedSecreted Proteins from Trypanosome Procyclic Strains. Journal of Biomedicine and Biotechnology. 2009. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-454961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454961