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The Treatment of Breast Cancer Using Liposome Technology
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Liposome-based chemotherapeutics used in the treatment of breast cancer can in principle enhance the therapeutic index of otherwise unencapsulated anticancer drugs.
This is partially attributed to the fact that encapsulation of cytotoxic agents within liposomes allows for increased concentrations of the drug to be delivered to the tumor site.
In addition, the presence of the phospholipid bilayer prevents the encapsulated active form of the drug from being broken down in the body prior to reaching tumor tissue and also serves to minimize exposure of the drug to healthy sensitive tissue.
While clinically approved liposome-based chemotherapeutics such as Doxil have proven to be quite effective in the treatment of breast cancer, significant challenges remain involving poor drug transfer between the liposome and cancerous cells.
In this review, we discuss the recent advancements made in the development of liposome-based chemotherapeutics with respect to improved drug transfer for use in breast cancer therapy.
American Psychological Association (APA)
Brown, Sarah& Khan, David R.. 2012. The Treatment of Breast Cancer Using Liposome Technology. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454976
Modern Language Association (MLA)
Brown, Sarah& Khan, David R.. The Treatment of Breast Cancer Using Liposome Technology. Journal of Drug Delivery No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-454976
American Medical Association (AMA)
Brown, Sarah& Khan, David R.. The Treatment of Breast Cancer Using Liposome Technology. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454976