Inflammation and Epstein-Barr Virus Infection Are Common Features of Myasthenia Gravis Thymus : Possible Roles in Pathogenesis
Joint Authors
Caldara, Rosa
Berrih-Aknin, Sonia
Antozzi, Carlo
Cavalcante, Paola
Maggi, Lorenzo
Bernasconi, Pia
Mantegazza, Renato
Colleoni, Lara
Giardina, Carmelo
Motta, Teresio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The thymus plays a major role in myasthenia gravis (MG).
Our recent finding of a persistent Epstein-Barr (EBV) virus infection in some MG thymuses, combined with data showing that the thymus is in a proinflammatory state in most patients, supports a viral contribution to the pathogenesis of MG.
Aim of this study was to gain further evidence for intrathymic chronic inflammation and EBV infection in MG patients.
Transcriptional profiling by low density array and real-time PCR showed overexpression of genes involved in inflammatory and immune response in MG thymuses.
Real-time PCR for EBV genome, latent (EBER1, EBNA1, LMP1) and lytic (BZLF1) transcripts, and immunohistochemistry for LMP1 and BZLF1 proteins confirmed an active intrathymic EBV infection, further supporting the hypothesis that EBV might contribute to onset or perpetuation of the autoimmune response in MG.
Altogether, our results support a role of inflammation and EBV infection as pathogenic features of MG thymus.
American Psychological Association (APA)
Cavalcante, Paola& Maggi, Lorenzo& Colleoni, Lara& Caldara, Rosa& Motta, Teresio& Giardina, Carmelo…[et al.]. 2011. Inflammation and Epstein-Barr Virus Infection Are Common Features of Myasthenia Gravis Thymus : Possible Roles in Pathogenesis. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-454981
Modern Language Association (MLA)
Cavalcante, Paola…[et al.]. Inflammation and Epstein-Barr Virus Infection Are Common Features of Myasthenia Gravis Thymus : Possible Roles in Pathogenesis. Autoimmune Diseases No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-454981
American Medical Association (AMA)
Cavalcante, Paola& Maggi, Lorenzo& Colleoni, Lara& Caldara, Rosa& Motta, Teresio& Giardina, Carmelo…[et al.]. Inflammation and Epstein-Barr Virus Infection Are Common Features of Myasthenia Gravis Thymus : Possible Roles in Pathogenesis. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-454981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454981