Inhibition of RNA Helicases of ssRNA+ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families
Joint Authors
Carta, Antonio
Corona, Paola
Briguglio, Irene
Piras, Sandra
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-16
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication.
General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy required for the unwinding and translocation, or by allosteric mechanism and therefore by stabilizing the conformation of the enzyme in low helicase activity state; inhibition of nucleic acids binding to the helicase; inhibition of coupling of ATP hydrolysis to unwinding; inhibition of unwinding by sterically blocking helicase translocation.
Recently, by in vitro screening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging to Flaviviridae, Coronaviridae, and Picornaviridae families.
American Psychological Association (APA)
Briguglio, Irene& Piras, Sandra& Corona, Paola& Carta, Antonio. 2010. Inhibition of RNA Helicases of ssRNA+ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-22.
https://search.emarefa.net/detail/BIM-454988
Modern Language Association (MLA)
Briguglio, Irene…[et al.]. Inhibition of RNA Helicases of ssRNA+ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-22.
https://search.emarefa.net/detail/BIM-454988
American Medical Association (AMA)
Briguglio, Irene& Piras, Sandra& Corona, Paola& Carta, Antonio. Inhibition of RNA Helicases of ssRNA+ Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families. International Journal of Medicinal Chemistry. 2010. Vol. 2011, no. 2011, pp.1-22.
https://search.emarefa.net/detail/BIM-454988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454988