Organic Nitrates and Nitrate Resistance in Diabetes : The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
Joint Authors
Oelze, Matthias
Daiber, Andreas
Schuhmacher, Swenja
Source
Experimental Diabetes Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy.
The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes.
Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start.
This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients.
This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies.
American Psychological Association (APA)
Oelze, Matthias& Schuhmacher, Swenja& Daiber, Andreas. 2010. Organic Nitrates and Nitrate Resistance in Diabetes : The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-454992
Modern Language Association (MLA)
Oelze, Matthias…[et al.]. Organic Nitrates and Nitrate Resistance in Diabetes : The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate. Experimental Diabetes Research No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-454992
American Medical Association (AMA)
Oelze, Matthias& Schuhmacher, Swenja& Daiber, Andreas. Organic Nitrates and Nitrate Resistance in Diabetes : The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate. Experimental Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-454992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454992