Molecular and Cellular Mechanism of Leukemogenesis of ATL : Emergent Evidence of a Significant Role for HBZ in HTLV-1-Induced Pathogenesis
Joint Authors
Satou, Yorifumi
Matsuoka, Masao
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Adult T-cell leukemia (ATL) is a leukemia derived from mature CD4+ T cells and induced by human T-cell leukemia virus type 1 (HTLV-1) infection.
Previous studies have revealed many possible molecular and cellular mechanisms of HTLV-1-induced leukemogenesis, but it still remains unknown how HTLV-1 transforms peripheral CD4 T cells in infected individuals.
Given the fact that only 2–5% of infected individuals develop ATL, HTLV-1 infection alone is not sufficient for the transformation of infected cells.
Host genetic and epigenetic abnormalities and host immunological status should be considered in attempting to understand the mechanism of the oncogenesis of ATL.
Nonetheless, it is obvious that HTLV-1 infection dramatically increases the risk of leukemia generation from peripheral CD4 T-cells, in which the incidence of leukemia is quite low.
Furthermore, the evidence that all ATL cases retain the HTLV-1 provirus, especially the 3′ region, indicates that HTLV-1-encoded genes play a critical role in leukemogenesis.
Since increasing evidence indicates that the HTLV-1 bZIP factor (HBZ) gene plays a significant role in the pathogenesis of HTLV-1, we will discuss the cellular and molecular mechanism of ATL generation from the virological point of view, particularly focusing on HBZ.
American Psychological Association (APA)
Satou, Yorifumi& Matsuoka, Masao. 2011. Molecular and Cellular Mechanism of Leukemogenesis of ATL : Emergent Evidence of a Significant Role for HBZ in HTLV-1-Induced Pathogenesis. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455029
Modern Language Association (MLA)
Satou, Yorifumi& Matsuoka, Masao. Molecular and Cellular Mechanism of Leukemogenesis of ATL : Emergent Evidence of a Significant Role for HBZ in HTLV-1-Induced Pathogenesis. Leukemia Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-455029
American Medical Association (AMA)
Satou, Yorifumi& Matsuoka, Masao. Molecular and Cellular Mechanism of Leukemogenesis of ATL : Emergent Evidence of a Significant Role for HBZ in HTLV-1-Induced Pathogenesis. Leukemia Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455029