The Electrophysiological Effects of Qiliqiangxin on Cardiac Ventricular Myocytes of Rats
Joint Authors
Jhummon, Muktanand Vikash
Li, Gang
Wei, Wanlin
Wei, Haidong
Wei, Yidong
Hou, Lei
The, Erlinda
Liu, Xiaoyu
Che, Wenliang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Qiliqiangxin, a Chinese herb, represents the affection in Ca channel function of cardiac myocytes.
It is unknown whether Qiliqiangxin has an effect on Na current and K current because the pharmacological actions of this herb’s compound are very complex.
We investigated the rational usage of Qiliqiangxin on cardiac ventricular myocytes of rats.
Ventricular myocytes were exposed acutely to 1, 10, and 50 mg/L Qiliqiangxin, and whole cell patch-clamp technique was used to study the acute effects of Qiliqiangxin on Sodium current (INa), outward currents delayed rectifier outward K+ current (IK), slowly activating delayed rectifier outward K+ current (IKs), transient outward K+ current (Ito), and inward rectifier K+ current (IK1).
Qiliqiangxin can decrease INa by 28.53%±5.98%, and its IC50 was 9.2 mg/L.
10 and 50 mg/L Qiliqiangxin decreased by 37.2%±6.4% and 55.9%±5.5% summit current density of Ito.
10 and 50 mg/L Qiliqiangxin decreased IKs by 15.51%±4.03% and 21.6%±5.6%.
Qiliqiangxin represented a multifaceted pharmacological profile.
The effects of Qiliqiangxin on Na and K currents of ventricular myocytes were more profitable in antiarrhythmic therapy in the clinic.
We concluded that the relative efficacy of Qiliqiangxin was another choice for the existing antiarrhythmic therapy.
American Psychological Association (APA)
Wei, Yidong& Liu, Xiaoyu& Wei, Haidong& Hou, Lei& Che, Wenliang& The, Erlinda…[et al.]. 2013. The Electrophysiological Effects of Qiliqiangxin on Cardiac Ventricular Myocytes of Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-455068
Modern Language Association (MLA)
Wei, Yidong…[et al.]. The Electrophysiological Effects of Qiliqiangxin on Cardiac Ventricular Myocytes of Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-455068
American Medical Association (AMA)
Wei, Yidong& Liu, Xiaoyu& Wei, Haidong& Hou, Lei& Che, Wenliang& The, Erlinda…[et al.]. The Electrophysiological Effects of Qiliqiangxin on Cardiac Ventricular Myocytes of Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-455068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455068