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Mouse Models of Aneuploidy
Joint Authors
Tybulewicz, Victor L. J.
Ruparelia, Aarti
Sheppard, Olivia
Wiseman, Frances K.
Fisher, Elizabeth M. C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Abnormalities of chromosome copy number are called aneuploidies and make up a large health load on the human population.
Many aneuploidies are lethal because the resulting abnormal gene dosage is highly deleterious.
Nevertheless, some whole chromosome aneuploidies can lead to live births.
Alterations in the copy number of sections of chromosomes, which are also known as segmental aneuploidies, are also associated with deleterious effects.
Here we examine how aneuploidy of whole chromosomes and segmental aneuploidy of chromosomal regions are modeled in the mouse.
These models provide a whole animal system in which we aim to investigate the complex phenotype-genotype interactions that arise from alteration in the copy number of genes.
Although our understanding of this subject is still in its infancy, already research in mouse models is highlighting possible therapies that might help alleviate the cognitive effects associated with changes in gene number.
Thus, creating and studying mouse models of aneuploidy and copy number variation is important for understanding what it is to be human, in both the normal and genomically altered states.
American Psychological Association (APA)
Sheppard, Olivia& Wiseman, Frances K.& Ruparelia, Aarti& Tybulewicz, Victor L. J.& Fisher, Elizabeth M. C.. 2012. Mouse Models of Aneuploidy. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455080
Modern Language Association (MLA)
Sheppard, Olivia…[et al.]. Mouse Models of Aneuploidy. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-455080
American Medical Association (AMA)
Sheppard, Olivia& Wiseman, Frances K.& Ruparelia, Aarti& Tybulewicz, Victor L. J.& Fisher, Elizabeth M. C.. Mouse Models of Aneuploidy. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455080