Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis?
Joint Authors
Goonetilleke, U. R.
Ward, S. A.
Gordon, S. B.
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Streptococcus pneumoniae is the most common bacterial cause of community-acquired meningitis worldwide.
Despite optimal antibiotic therapy and supportive care, the mortality of this condition remains very high at 20–30% in the developed world and over 60% in under-resourced hospitals.
In developed countries, approximately half of the survivors suffer intellectual impairment, hearing loss, or other neurological damage.
There is an urgent need for more information about the mechanisms of brain damage and death in pneumococcal meningitis so that new treatments can be designed.
Using proteomic techniques and bioinformatics, the protein content of cerebrospinal fluid can be examined in great detail.
Animal models have added greatly to our knowledge of possible mechanisms and shown that hippocampal apoptosis and cortical necrosis are distinct mechanisms of neuronal death.
The contribution of these pathways to human disease is unknown.
Using proteomic techniques, neuronal death pathways could be described in CSF samples.
This information could lead to the design of novel therapies to minimize brain damage and lower mortality.
This minireview will summarize the known pathogenesis of meningitis, and current gaps in knowledge, that could be filled by proteomic analysis.
American Psychological Association (APA)
Goonetilleke, U. R.& Ward, S. A.& Gordon, S. B.. 2009. Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis?. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-455099
Modern Language Association (MLA)
Goonetilleke, U. R.…[et al.]. Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis?. Interdisciplinary Perspectives on Infectious Diseases No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-455099
American Medical Association (AMA)
Goonetilleke, U. R.& Ward, S. A.& Gordon, S. B.. Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis?. Interdisciplinary Perspectives on Infectious Diseases. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-455099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455099