Molecular Determinants for the Self-Assembly of Elastin Peptides
Joint Authors
Crudele, Maria Antonietta
Armenante, Maria Rosaria
Pepe, Antonietta
Bochicchio, Brigida
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Elastin and elastin-related peptides have great potential in the biomaterial field, because of their peculiar mechanical properties and spontaneous self-assembling behavior.
Depending on their sequences and under appropriate experimental conditions, they are able to self-assemble in different fiber morphologies, including amyloid-like fibers.
In this work, we will review recent data on elastin peptides derived from exon 30-coded domain of human tropoelastin.
This domain has been shown to be fundamental for the correct assembly of elastin.
However, the N-terminal region forms amyloid-like fibers, while the C-terminal fragment forms elastin-like fibers.
A rationale for the varied aggregation pattern has been sought in the molecular structure of the peptides.
Minimal differences in the sequences, adopting alternative conformations, are shown to be responsible for the observed data.
American Psychological Association (APA)
Bochicchio, Brigida& Armenante, Maria Rosaria& Crudele, Maria Antonietta& Pepe, Antonietta. 2014. Molecular Determinants for the Self-Assembly of Elastin Peptides. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-455102
Modern Language Association (MLA)
Bochicchio, Brigida…[et al.]. Molecular Determinants for the Self-Assembly of Elastin Peptides. Conference Papers in Science No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-455102
American Medical Association (AMA)
Bochicchio, Brigida& Armenante, Maria Rosaria& Crudele, Maria Antonietta& Pepe, Antonietta. Molecular Determinants for the Self-Assembly of Elastin Peptides. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-455102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455102