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Involvement of COX-2PGE2 Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer
Joint Authors
Zhao, Chenghai
Dai, Xianwei
Bu, Xianmin
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
COX-2 and MMP-9 have been reported to show an overexpression in pancreatic cancer, and thus an attempt to explore the correlation between them has become a target of this study.
Besides, PGE2, a product of COX-2, was also under research as to whether it is involved in the upregulation of MMP-9 expression by COX-2.
Expression of COX-2 and MMP-9 mRNA varied in pancreatic adenocarcinomas, and the mRNA level of COX-2 was correlated positively with MMP-9.
Both BxPC-3 and Capan-1 cells had strong expression of COX-2 and MMP-9.
MMP-9 expression was downregulated significantly in BxPC-3 and Capan-1 cells after treatment with COX-2 inhibitors or COX-2 siRNA plasmids, and upregulated in BxPC-3 significantly by exogenous TNF-α, LPS or PGE2.
The upregulation of MMP-9 by TNF-α or LPS was inhibited by COX-2 inhibitor NS398.
There was a significant increase in the migration of BxPC-3 cells with TNF-α, LPS, or PGE2 treatment; however, the increase caused by TNF-α or LPS was also inhibited remarkably by NS398.
Our findings demonstrated that COX-2 upregulates MMP-9 expression in pancreatic cancer, and PGE2 may be involved in it.
American Psychological Association (APA)
Bu, Xianmin& Zhao, Chenghai& Dai, Xianwei. 2011. Involvement of COX-2PGE2 Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455106
Modern Language Association (MLA)
Bu, Xianmin…[et al.]. Involvement of COX-2PGE2 Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer. Gastroenterology Research and Practice No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-455106
American Medical Association (AMA)
Bu, Xianmin& Zhao, Chenghai& Dai, Xianwei. Involvement of COX-2PGE2 Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455106