New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal
Joint Authors
El-Mammli, Magda Y.
Hassan, Wafaa S.
Sayed, Rania A.
Shalaby, Abadalla
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Two Simple, accurate, precise, and rapid spectrophotometric and conductometric methods were developed for the estimation of erythromycin thiocyanate (I), clarithromycin (II), and azithromycin dihydrate (III) in both pure and pharmaceutical dosage forms.
The spectrophotometric procedure depends on the reaction of rose bengal and copper with the cited drugs to form stable ternary complexes which are extractable with methylene chloride, and the absorbances were measured at 558, 557, and 560 nm for (I), (II), and (III), respectively.
The conductometric method depends on the formation of an ion-pair complex between the studied drug and rose bengal.
For the spectrophotometric method, Beer's law was obeyed.
The correlation coefficient (r2) for the studied drugs was found to be 0.9999.
The molar absorptivity (ε), Sandell’s sensitivity, limit of detection (LOD), and limit of quantification (LOQ) were also calculated.
The proposed methods were successfully applied for the determination of certain pharmaceutical dosage forms containing the studied drugs
American Psychological Association (APA)
Sayed, Rania A.& Hassan, Wafaa S.& El-Mammli, Magda Y.& Shalaby, Abadalla. 2013. New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal. Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-455107
Modern Language Association (MLA)
Sayed, Rania A.…[et al.]. New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal. Journal of Spectroscopy No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-455107
American Medical Association (AMA)
Sayed, Rania A.& Hassan, Wafaa S.& El-Mammli, Magda Y.& Shalaby, Abadalla. New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal. Journal of Spectroscopy. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-455107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455107