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Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation : A Short Review
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
At the time when the highly efficient [18F]FDG synthesis was discovered by the use of the effective precursor 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate) for nucleophilic 18F-substitution, the field of PET in nuclear medicine experienced a long-term boom.
Thirty years later, various strategies for chemoselective 18F-labeling of biomolecules have been developed, trying to keep up with the emerging field of radiopharmaceutical sciences.
Among the new radiochemical strategies, chemoselective 18F-fluoroglycosylation methods aim at the sweetening of pharmaceutical radiochemistry by providing a powerful and highly valuable tool for the design of 18F-glycoconjugates with suitable in vivo properties for PET imaging studies.
This paper provides a short review (reflecting the literature not older than 8 years) on the different 18F-fluoroglycosylation reactions that have been applied to the development of various 18F-glycoconjugate tracers, including not only peptides, but also nonpeptidic tracers and high-molecular-weight proteins.
American Psychological Association (APA)
Maschauer, Simone& Prante, Olaf. 2014. Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation : A Short Review. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-455142
Modern Language Association (MLA)
Maschauer, Simone& Prante, Olaf. Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation : A Short Review. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-455142
American Medical Association (AMA)
Maschauer, Simone& Prante, Olaf. Sweetening Pharmaceutical Radiochemistry by 18F-Fluoroglycosylation : A Short Review. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-455142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455142