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Varicella Zoster Virus and Relapsing Remitting Multiple Sclerosis
Joint Authors
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Multiple sclerosis (MS) is an immune-mediated disorder; however, little is known about the triggering factors of the abnormal immune response.
Different viruses from the herpes family have been mentioned as potential participants.
Here, we review the evidences that support the association of varicella zoster virus (VZV) with MS.
Epidemiological studies from geographical areas, where incidence of MS has increased in recent decades, pointed out a high frequency of varicella and zoster in the clinical antecedents of MS patients, and also laboratory investigations have found large quantities of DNA from VZV in leucocytes and cerebrospinal fluid of MS patients restricted to the ephemeral period of MS relapse, followed by disappearance of the virus during remission.
The above observations and the peculiar features of VZV, mainly characterized by its neurotropism and long periods of latency followed by viral reactivation, support the idea on the participation of VZV in the etiology of MS.
However, as with reports from studies with other viruses, particularly Epstein Barr virus, conflicting results on confirmatory studies about the presence of viral gene products in brain tissue indicate the need for further research on the potential participation of VZV in the etiology of MS.
American Psychological Association (APA)
Sotelo, Julio& Corona, Teresa. 2011. Varicella Zoster Virus and Relapsing Remitting Multiple Sclerosis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-455146
Modern Language Association (MLA)
Sotelo, Julio& Corona, Teresa. Varicella Zoster Virus and Relapsing Remitting Multiple Sclerosis. Multiple Sclerosis International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-455146
American Medical Association (AMA)
Sotelo, Julio& Corona, Teresa. Varicella Zoster Virus and Relapsing Remitting Multiple Sclerosis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-455146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455146