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Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats
Joint Authors
Kawu, Mohammed U.
Abubakar, Woziri O.
Orieji, Chinedu
Shittu, Muftau
Ambali, Suleiman F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb).
Forty Wistar rats were divided into 4 groups of 10 animals each.
Groups I and II were administered soya oil (2 mL/kg) and vitamin C (100 mg/kg), respectively.
Group III was coadministered CPF (4.25 mg/kg ~1/20th LD50) and Pb (250 mg/kg ~1/20th LD50), respectively.
Group IV was pretreated with vitamin C (100 mg/kg) and then coadministered with CPF (4.25 mg/kg) and Pb (250 mg/kg), 30 min later.
The regimens were administered by gavage for a period of 9 weeks.
The marginal decrease in serum triiodothyronine and thyroxine and the significant increase in the concentrations of thyroid stimulating hormone and malonaldehyde in the group coadministered with CPF and Pb were ameliorated by vitamin C partly due to its antioxidant properties.
American Psychological Association (APA)
Ambali, Suleiman F.& Orieji, Chinedu& Abubakar, Woziri O.& Shittu, Muftau& Kawu, Mohammed U.. 2011. Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-455163
Modern Language Association (MLA)
Ambali, Suleiman F.…[et al.]. Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats. Journal of Thyroid Research No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-455163
American Medical Association (AMA)
Ambali, Suleiman F.& Orieji, Chinedu& Abubakar, Woziri O.& Shittu, Muftau& Kawu, Mohammed U.. Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-455163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455163