The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
Joint Authors
Cerella, Claudia
Dicato, Mario
Ghibelli, Lina
Diederich, Marc
Sobolewski, Cyril
Source
International Journal of Cell Biology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-17
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis.
The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin biosynthesis.
This family contains three members: ubiquitously expressed COX-1, which is involved in homeostasis; the inducible COX-2 isoform, which is upregulated during both inflammation and cancer; and COX-3, expressed in brain and spinal cord, whose functions remain to be elucidated.
COX-2 was described to modulate cell proliferation and apoptosis mainly in solid tumors, that is, colorectal, breast, and prostate cancers, and, more recently, in hematological malignancies.
These findings prompt us to analyze here the effects of a combination of COX-2 inhibitors together with different clinically used therapeutic strategies in order to further improve the efficiency of future anticancer treatments.
COX-2 modulation is a promising field investigated by many research groups.
American Psychological Association (APA)
Sobolewski, Cyril& Cerella, Claudia& Dicato, Mario& Ghibelli, Lina& Diederich, Marc. 2010. The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-455186
Modern Language Association (MLA)
Sobolewski, Cyril…[et al.]. The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies. International Journal of Cell Biology No. 2010 (2010), pp.1-21.
https://search.emarefa.net/detail/BIM-455186
American Medical Association (AMA)
Sobolewski, Cyril& Cerella, Claudia& Dicato, Mario& Ghibelli, Lina& Diederich, Marc. The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies. International Journal of Cell Biology. 2010. Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-455186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455186