B Cells in Autoimmune Diseases
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
The role of B cells in autoimmune diseases involves different cellular functions, including the well-established secretion of autoantibodies, autoantigen presentation and ensuing reciprocal interactions with T cells, secretion of inflammatory cytokines, and the generation of ectopic germinal centers.
Through these mechanisms B cells are involved both in autoimmune diseases that are traditionally viewed as antibody mediated and also in autoimmune diseases that are commonly classified as T cell mediated.
This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases.
This paper includes an overview of the different functions of B cells in autoimmunity; the involvement of B cells in systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes; and current B-cell-based therapeutic treatments.
We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells.
American Psychological Association (APA)
Hampe, Christiane S.. 2012. B Cells in Autoimmune Diseases. Scientifica،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-455203
Modern Language Association (MLA)
Hampe, Christiane S.. B Cells in Autoimmune Diseases. Scientifica No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-455203
American Medical Association (AMA)
Hampe, Christiane S.. B Cells in Autoimmune Diseases. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-455203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455203