Mapping Remote Subcortical Ramifications of Injury after Ischemic Strokes
Joint Authors
Bonilha, Leonardo
Fillmore, Paul
Ratnayake, Ruwan P.
Rorden, Chris
Nesland, Travis
Fridriksson, Julius
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI).
However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical symptoms ensue after subcortical damage.
This observation suggests that disconnection or diaschisis can lead to remote cortical dysfunction that can be functionally equivalent to direct cortical lesions.
Objective.
To directly measure subcortical disconnection after stroke.
Methods.
We describe a principled approach utilizing the whole brain connectome reconstructed from diffusion MRI to evaluate the reduction of apparent white matter fiber density in the hemisphere affected by the stroke compared with the spared hemisphere.
Results.
In eight chronic stroke patients, we observed subcortical disconnection extending beyond the location of tissue necrosis and affecting major white matter pathways underlying the necrotic area.
Conclusions.
We suggest that it is possible to detect and quantify previously unappreciated areas of subcortical and cortical disconnection.
Specifically, this method can be used to evaluate the relationship between lesion location and symptoms, with emphasis on a connectivity-based approach.
American Psychological Association (APA)
Bonilha, Leonardo& Nesland, Travis& Rorden, Chris& Fillmore, Paul& Ratnayake, Ruwan P.& Fridriksson, Julius. 2014. Mapping Remote Subcortical Ramifications of Injury after Ischemic Strokes. Behavioural Neurology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-455211
Modern Language Association (MLA)
Bonilha, Leonardo…[et al.]. Mapping Remote Subcortical Ramifications of Injury after Ischemic Strokes. Behavioural Neurology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-455211
American Medical Association (AMA)
Bonilha, Leonardo& Nesland, Travis& Rorden, Chris& Fillmore, Paul& Ratnayake, Ruwan P.& Fridriksson, Julius. Mapping Remote Subcortical Ramifications of Injury after Ischemic Strokes. Behavioural Neurology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-455211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455211