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Thyroid Hormone and the Neuroglia : Both Source and Target
Joint Authors
Zeöld, Anikó
Gereben, Balázs
Bianco, Antonio C.
Mohácsik, Petra
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Thyroid hormone plays a crucial role in the development and function of the nervous system.
In order to bind to its nuclear receptor and regulate gene transcription thyroxine needs to be activated in the brain.
This activation occurs via conversion of thyroxine to T3, which is catalyzed by the type 2 iodothyronine deiodinase (D2) in glial cells, in astrocytes, and tanycytes in the mediobasal hypothalamus.
We discuss how thyroid hormone affects glial cell function followed by an overview on the fine-tuned regulation of T3 generation by D2 in different glial subtypes.
Recent evidence on the direct paracrine impact of glial D2 on neuronal gene expression underlines the importance of glial-neuronal interaction in thyroid hormone regulation as a major regulatory pathway in the brain in health and disease.
American Psychological Association (APA)
Mohácsik, Petra& Zeöld, Anikó& Bianco, Antonio C.& Gereben, Balázs. 2011. Thyroid Hormone and the Neuroglia : Both Source and Target. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-455233
Modern Language Association (MLA)
Mohácsik, Petra…[et al.]. Thyroid Hormone and the Neuroglia : Both Source and Target. Journal of Thyroid Research No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-455233
American Medical Association (AMA)
Mohácsik, Petra& Zeöld, Anikó& Bianco, Antonio C.& Gereben, Balázs. Thyroid Hormone and the Neuroglia : Both Source and Target. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-455233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455233