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The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses
Joint Authors
Rumbullaku, Margarita
Pesce, Giampaola
Simone, Rita
Saverino, Daniele
Antola, Princey
Bagnasco, Marcello
Bizzaro, Nicola
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is a costimulatory receptor transducing a potent inhibitory signal.
Increasing evidence showed that CTLA-4 gene is an important susceptibility locus for autoimmune disorders.
Alternatively spliced mRNA generates a soluble form, called sCTLA-4.
Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.
The biological significance of increased sCTLA-4 serum level is not fully clarified yet.
It can be envisaged that sCTLA-4 specifically inhibits the early T-cell activation by blocking the interaction of CD80/CD86 with the costimulatory receptor CD28.
On the other hand, higher levels of sCTLA-4 could contend the binding of the membrane form of CTLA-4 with CD80/CD86, in later activation phase, causing a reduction of inhibitory signalling.
We showed that sCTLA-4 from sera of patients with different autoimmune diseases is able to display functional activities on an in vitro system acting on the proliferation capability and modulating the secretion of cytokines.
We observed a dual effect of sCTLA-4: inhibiting the secretion of IFN-γ, IL-2, IL-7, and IL-13 and activating the secretion of TGF-β and IL-10.
This study underlines the role of sCTLA-4 in modulating the immune response and its relevance in autoimmune disease pathogenesis.
American Psychological Association (APA)
Simone, Rita& Pesce, Giampaola& Antola, Princey& Rumbullaku, Margarita& Bagnasco, Marcello& Bizzaro, Nicola…[et al.]. 2014. The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-455236
Modern Language Association (MLA)
Simone, Rita…[et al.]. The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-455236
American Medical Association (AMA)
Simone, Rita& Pesce, Giampaola& Antola, Princey& Rumbullaku, Margarita& Bagnasco, Marcello& Bizzaro, Nicola…[et al.]. The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-455236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455236