Genetic and Epigenetic Tumor Suppressor Gene Silencing Are Distinct Molecular Phenotypes Driven by Growth Promoting Mutations in Nonsmall Cell Lung Cancer
Joint Authors
Kelsey, Karl T.
Nelson, Heather H.
Houseman, E. Andres
Marsit, Carmen J.
Source
Journal of Cancer Epidemiology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Both genetic and epigenetic alterations characterize human nonsmall cell lung cancer (NSCLC), but the biological processes that create or select these alterations remain incompletely investigated.
Our hypothesis posits that a roughly reciprocal relationship between the propensity for promoter hypermethylation and a propensity for genetic deletion leads to distinct molecular phenotypes of lung cancer.
To test this hypothesis, we examined promoter hypermethylation of 17 tumor suppressor genes, as a marker of epigenetic alteration propensity, and deletion events at the 3p21 region, as a marker of genetic alteration.
To model the complex biology between these somatic alterations, we utilized an item response theory model.
We demonstrated that tumors exhibiting LOH at greater than 30% of informative alleles in the 3p21 region have a significantly reduced propensity for hypermethylation.
At the same time, tumors with activating KRAS mutations showed a significantly increased propensity for hypermethylation of the loci examined, a result similar to what has been observed in colon cancer.
These data suggest that NSCLCs have distinct epigenetic or genetic alteration phenotypes acting upon tumor suppressor genes and that mutation of oncogenic growth promoting genes, such as KRAS, is associated with the epigenetic phenotype.
American Psychological Association (APA)
Marsit, Carmen J.& Houseman, E. Andres& Nelson, Heather H.& Kelsey, Karl T.. 2009. Genetic and Epigenetic Tumor Suppressor Gene Silencing Are Distinct Molecular Phenotypes Driven by Growth Promoting Mutations in Nonsmall Cell Lung Cancer. Journal of Cancer Epidemiology،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-455242
Modern Language Association (MLA)
Marsit, Carmen J.…[et al.]. Genetic and Epigenetic Tumor Suppressor Gene Silencing Are Distinct Molecular Phenotypes Driven by Growth Promoting Mutations in Nonsmall Cell Lung Cancer. Journal of Cancer Epidemiology No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-455242
American Medical Association (AMA)
Marsit, Carmen J.& Houseman, E. Andres& Nelson, Heather H.& Kelsey, Karl T.. Genetic and Epigenetic Tumor Suppressor Gene Silencing Are Distinct Molecular Phenotypes Driven by Growth Promoting Mutations in Nonsmall Cell Lung Cancer. Journal of Cancer Epidemiology. 2009. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-455242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455242