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Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults : A Meta-Analysis
Joint Authors
Yang, Jie
Li, Yukun
Wang, Yan
Xue, Peng
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objectives.
Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults.
The aim of this study was to determine whether the growth hormone replacement therapy could elevate bone mineral density in growth hormone deficient adults.
Methods.
In this meta-analysis, searches of Medline, Embase, and The Cochrane Library were undertaken to identify studies in humans of the association between growth hormone treatment and bone mineral density in growth hormone deficient adults.
Random effects model was used for this meta-analysis.
Results.
A total of 20 studies (including one outlier study) with 936 subjects were included in our research.
We detected significant overall association of growth hormone treatment with increased bone mineral density of spine, femoral neck, and total body, but some results of subgroup analyses were not consistent with the overall analyses.
Conclusions.
Our meta-analysis suggested that growth hormone replacement therapy could have beneficial influence on bone mineral density in growth hormone deficient adults, but, in some subject populations, the influence was not evident.
American Psychological Association (APA)
Xue, Peng& Wang, Yan& Yang, Jie& Li, Yukun. 2013. Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults : A Meta-Analysis. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-455275
Modern Language Association (MLA)
Xue, Peng…[et al.]. Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults : A Meta-Analysis. International Journal of Endocrinology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-455275
American Medical Association (AMA)
Xue, Peng& Wang, Yan& Yang, Jie& Li, Yukun. Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults : A Meta-Analysis. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-455275
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455275