Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma
Joint Authors
Wang, Jue
Hemstreet III, George P.
Wang, Fen Wei
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The aim of this study was to examine the epidemiology, natural history, treatment pattern, and predictors of long-term survival of signet ring prostate carcinoma (SRPC) patients based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER) database.
Methods & Results.
Between 1980 and 2004, a total of 93 patients with pathologically confirmed SRPC were identified.
The mean age was 70±11 years old.
82.8% of the patients had poorly or undifferentiated histology grade.
13.9% patients presented with metastatic disease.
The 1-, 3-, and 5-year cancer-specific survival rates were 94.6%, 89.6%, and 83.8%, respectively.
Using multivariate Cox proportional hazard model, younger age (40–50 versus age >70 yrs, P=.01), advanced tumor stage (distant versus local/regional, P=.02), and earlier diagnosis year (before 1995 versus after 1995, P=.01) were predictors of worse cancer specific survival.
Conclusions.
Despite more aggressive cancer therapy, younger SRPC patients had a worse cancer specific survival.
This information could be useful when counseling these patients and emphasizes the need for new strategies and molecular-based therapeutic approaches for younger patients with SRPC.
American Psychological Association (APA)
Wang, Jue& Wang, Fen Wei& Hemstreet III, George P.. 2010. Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma. Prostate Cancer،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455279
Modern Language Association (MLA)
Wang, Jue…[et al.]. Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma. Prostate Cancer No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-455279
American Medical Association (AMA)
Wang, Jue& Wang, Fen Wei& Hemstreet III, George P.. Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma. Prostate Cancer. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-455279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455279