Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries
Author
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Alcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell.
Excessive alcohol consumption induces numerous pathological stress responses, part of which is endoplasmic reticulum (ER) stress response.
ER stress, a condition under which unfolded/misfolded protein accumulates in the ER, contributes to alcoholic disorders of major organs such as liver, pancreas, heart, and brain.
Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications.
Interruption of the ER stress triggers is anticipated to have therapeutic benefits for alcoholic disorders.
American Psychological Association (APA)
Ji, Cheng. 2011. Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-455312
Modern Language Association (MLA)
Ji, Cheng. Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries. Biochemistry Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-455312
American Medical Association (AMA)
Ji, Cheng. Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries. Biochemistry Research International. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-455312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455312