Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo
Joint Authors
Garbacz, Wojciech G.
Palmer, Colin N. A.
Gustafsson, Mattias C. U.
Wolf, C. Roland
Ashby, Peter R.
Higgins, Larry G.
Nainamalai, Sitheswaran
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The nuclear receptor, NR1C2 or peroxisome proliferator-activated receptor (PPAR)-δ, is ubiquitously expressed and important for placental development, fatty acid metabolism, wound healing, inflammation, and tumour development.
PPARδ has been hypothesized to function as both a ligand activated transcription factor and a repressor of transcription in the absence of agonist.
In this paper, treatment of mice conditionally expressing human PPARδ with GW501516 resulted in a marked loss in body weight that was not evident in nontransgenic animals or animals expressing a dominant negative derivative of PPARδ.
Expression of either functional or dominant negative hPPARδ blocked bezafibrate-induced PPARα-dependent hepatomegaly and blocked the effect of bezafibrate on the transcription of PPARα target genes.
These data demonstrate, for the first time, that PPARδ could inhibit the activation of PPARα in vivo and provide novel models for the investigation of the role of PPARδ in pathophysiology.
American Psychological Association (APA)
Higgins, Larry G.& Garbacz, Wojciech G.& Gustafsson, Mattias C. U.& Nainamalai, Sitheswaran& Ashby, Peter R.& Wolf, C. Roland…[et al.]. 2012. Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo. PPAR Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-455343
Modern Language Association (MLA)
Higgins, Larry G.…[et al.]. Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo. PPAR Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-455343
American Medical Association (AMA)
Higgins, Larry G.& Garbacz, Wojciech G.& Gustafsson, Mattias C. U.& Nainamalai, Sitheswaran& Ashby, Peter R.& Wolf, C. Roland…[et al.]. Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-455343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455343