A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis : Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy
Joint Authors
Peng, Yan
Han, Jeong S.
Sarode, Venetia R.
Rao, Roshni
Morris, Danielle H.
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a paucity of data regarding molecular subtypes of pure ductal carcinoma in situ (pDCIS).
We evaluated the expression of ER, PR, HER2, Ki67, and p53 and DNA ploidy in 118 pDCIS and 100 invasive breast carcinomas (IBCAs) by routine IHC and classified them according to molecular subtypes.
Quantification of biomarkers and DNA ploidy was performed by image analysis.
Expression of ER, PR, and high ki67 was more frequent in pDCIS compared to IBCA.
High-grade tumors had lower ER and PR expression, high Ki67, overexpression of HER2 and p53, and DNA aneuploidy.
Luminal A and HER2 subtypes were more common in pDCIS, and triple negative was more prevalent in IBCA.
In both groups, HER2 and triple negative subtypes were characterized by high ki67, overexpression of p53, and DNA aneuploidy compared to luminal subtypes.
Molecular subtypes of IBCA are distinct from those of pDCIS.
Invasion is characterized by change in phenotype in some tumors.
American Psychological Association (APA)
Sarode, Venetia R.& Han, Jeong S.& Morris, Danielle H.& Peng, Yan& Rao, Roshni. 2011. A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis : Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455361
Modern Language Association (MLA)
Sarode, Venetia R.…[et al.]. A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis : Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy. International Journal of Breast Cancer No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-455361
American Medical Association (AMA)
Sarode, Venetia R.& Han, Jeong S.& Morris, Danielle H.& Peng, Yan& Rao, Roshni. A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis : Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-455361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455361